Thursday, September 25, 2008

Protein of the Day #7: Enolase

Mammals have three enolases. A more descriptive name is "phosphopyruvate hydratase" - they catalyze the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate.

In Plasmodium falciparum, there is still some controversy about their enolase. It appears that at least part of it comes from a migration from the apicoplast genome into the nuclear genome, but it may be a hybrid. Here's the telltale insertion that matches up with plants (in this case rice, but the apicoplast probably came from a red algae ancestor endosymbiont):

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